Detalhe da pesquisa
1.
Design, synthesis and biological evaluation of 2,3-dihydroimidazo[2,1-b]thiazoles as dual EGFR and IGF1R inhibitors.
Bioorg Chem
; 115: 105151, 2021 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-34333424
2.
Water-soluble prodrugs of paclitaxel containing self-immolative disulfide linkers.
Bioorg Med Chem Lett
; 25(1): 122-7, 2015 Jan 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-25466201
3.
P7170, a novel inhibitor of mTORC1/mTORC2 and Activin receptor-like Kinase 1 (ALK1) inhibits the growth of non small cell lung cancer.
Mol Cancer
; 13: 259, 2014 Dec 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-25466244
4.
Lead optimization of isocytosine-derived xanthine oxidase inhibitors.
Bioorg Med Chem Lett
; 23(3): 834-8, 2013 Feb 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-23265878
5.
Isocytosine-based inhibitors of xanthine oxidase: design, synthesis, SAR, PK and in vivo efficacy in rat model of hyperuricemia.
Bioorg Med Chem Lett
; 22(24): 7543-6, 2012 Dec 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-23122864
6.
Validation of quinidine as a probe substrate for the in vitro P-gp inhibition assay in Caco-2 cell monolayer.
Eur J Drug Metab Pharmacokinet
; 36(3): 115-9, 2011 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-21725799
7.
Development and validation of RP-HPLC-fluorescence method for quantitative determination of quinidine, a probe substrate for P-glycoprotein inhibition assay using Caco-2 cell monolayer.
Biomed Chromatogr
; 24(6): 620-5, 2010 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-19816852
8.
In vitro evaluation of hepatic and extra-hepatic metabolism of coumarins using rat subcellular fractions: correlation of in vitro clearance with in vivo data.
Drug Metabol Drug Interact
; 23(3-4): 329-50, 2008.
Artigo
em Inglês
| MEDLINE | ID: mdl-19326776
9.
Cyclopentyl-pyrimidine based analogues as novel and potent IGF-1R inhibitor.
Eur J Med Chem
; 92: 246-56, 2015 Mar 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-25559205
10.
P7170: A Novel Molecule with Unique Profile of mTORC1/C2 and Activin Receptor-like Kinase 1 Inhibition Leading to Antitumor and Antiangiogenic Activity.
Mol Cancer Ther
; 14(5): 1095-106, 2015 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-25700704
11.
Effect of the excipient concentration on the pharmacokinetics of PM181104, a novel antimicrobial thiazolyl cyclic peptide antibiotic, following intravenous administration to mice.
Results Pharma Sci
; 4: 34-41, 2014.
Artigo
em Inglês
| MEDLINE | ID: mdl-25756005
12.
Synthesis of N-(6-(4-(Piperazin-1-yl)phenoxy)pyridin-3-yl)benzenesulfonamide Derivatives for the Treatment of Metabolic Syndrome.
Int J Med Chem
; 2013: 201580, 2013.
Artigo
em Inglês
| MEDLINE | ID: mdl-25374688
13.
Discovery of P3971 an orally efficacious novel anticancer agent targeting HIF-1α and STAT3 pathways.
Anticancer Agents Med Chem
; 13(9): 1460-6, 2013 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-24102269
14.
Evaluation of thiazole containing biaryl analogs as diacylglycerol acyltransferase 1 (DGAT1) inhibitors.
Eur J Med Chem
; 65: 337-47, 2013 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-23735282
15.
Synthesis of N-(5-chloro-6-(quinolin-3-yloxy)pyridin-3-yl)benzenesulfonamide derivatives as non-TZD peroxisome proliferator-activated receptor γ (PPARγ) agonist.
Eur J Med Chem
; 58: 355-60, 2012 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-23142675
16.
Fermentation, Isolation, Structure, and antidiabetic activity of NFAT-133 produced by Streptomyces strain PM0324667.
AMB Express
; 1(1): 42, 2011 Nov 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-22104600
17.
Determination of site of absorption of propranolol in rat gut using in situ single-pass intestinal perfusion.
Indian J Pharm Sci
; 72(5): 625-9, 2010 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-21694996
18.
Preparation and characterization of rodent intestinal microsomes: comparative assessment of two methods.
Indian J Pharm Sci
; 71(1): 75-7, 2009 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-20177465
19.
18F9 (4-(3,6-bis (ethoxycarbonyl)-4,5,6,7-tetrahydrothieno (2,3-c) pyridin-2-ylamino)-4-oxobutanoic acid) enhances insulin-mediated glucose uptake in vitro and exhibits antidiabetic activity in vivo in db/db mice.
Metabolism
; 58(10): 1503-16, 2009 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-19608207